The Niners have a chance to go for perfect 8-0 on Primetime Thursday Night in a divisional game against Arizona.

The 49ers are coming off a short week as they played and crushed the Carolina Panthers on Sunday. Final Score: Panthers 13 – 49ers 51 (ouch!)

Arizona also played on Sunday and lost 9 to 31 versus the New Orleans Saints.

The line is quite high at Cardinals +10, so the question is if this is an overreaction from the public or is it justified?

The fact is that the 49ers is the better team overall here, however, taking into account the point spread, do the Cardinals stand a chance?

History says YES. The Arizona Cardinals are 8-0 vs the 49ers since 2015

Game Prediction

The San Francisco 49ers defense is #1 in the NFL, and this is bad news for the Cardinals offense of line who have allowed Kyler Murray to be sacked 27 times in 8 games. That being said, the Cardinals know how to play and win over Niners, plus, tonight is Halloween and weird things happen! Expect the upset, take the Cardinals +10.

49ers vs Cardinals Prediction -Oct 31